WeFollow is a new user powered Twitter directory with the intention of making it easier to find people to follow.
In Digg Founder Launches WeFollow Twitter Directory it says:
Digg founder Kevin Rose has launched a Twitter directory called WeFollow to address the issue( finding the right people to follow).
To get yourself listed, simply send an @ reply message to WeFollow with three tags that you would like to be identified by, and WeFollow will add you to the directory for those tags.
For instance, tweeting “@wefollow #tech #music #nyc” will get you listed under the tags for Tech, Music, and NYC.
I signed up with “@wefollow #coach #lifecoach #blogger” and found out that I was the first one using the tag lifecoach.